Staphylococcal Chromosomal Cassette mec Composite Island with Significant 2 Homology to Staphylococcus epidermidis ACME type II in Methicillin-
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چکیده
5 Anna C. Shore , Angela S. Rossney , Orla M. Brennan , Peter M. Kinnevey , Hilary 6 Humphreys , Derek J. Sullivan , Richard V. Goering , Ralf Ehricht , Stefan Monecke , 7 and David C. Coleman 1* 8 9 Microbiology Research Unit, Dublin Dental University Hospital, University of Dublin, Trinity 10 College Dublin, Ireland. National MRSA Reference Laboratory, Dublin, Ireland. 11 Department of Clinical Microbiology, The Royal College of Surgeons in Ireland, Dublin, 12 Ireland. Department of Microbiology, Beaumont Hospital, Dublin, Ireland. Creighton 13 University, Omaha, Nebraska, USA. Alere Technologies GmbH, Jena, Germany. 14 Institute for Medical Microbiology and Hygiene, Faculty of Medicine "Carl Gustav Carus", 15 Technical University of Dresden, Germany. 16 17
منابع مشابه
Two novel arginine catabolic mobile elements and staphylococcal chromosome cassette mec composite islands in community-acquired methicillin-resistant Staphylococcus aureus genotypes ST5-MRSA-V and ST5-MRSA-II.
OBJECTIVES The arginine catabolic mobile element (ACME) is a novel staphylococcal genetic island. ACME is located downstream of the staphylococcal cassette chromosome mec (SCCmec), forming the ACME-SCCmec composite island. Recently, ACME II (located upstream of SCCmec IV) was described from a methicillin-resistant Staphylococcus aureus (MRSA) strain M1 in Denmark (ST8-MRSA-IVa) and 15 MRSA isol...
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In methicillin resistant Staphylococcus aureus (MRSA), the arginine catabolic mobile element (ACME) was initially described in USA300 (t008-ST8) where it is located downstream of the staphylococcal cassette chromosome mec (SCCmec). A common health-care associated MRSA in Copenhagen, Denmark (t024-ST8) is clonally related to USA300 and is frequently PCR positive for the ACME specific arcA-gene. ...
متن کاملGenome-wide analysis reveals two novel mosaic regions containing an ACME with an identical DNA sequence in the MRSA ST398-t011 and MSSA ST8-t008 isolates.
OBJECTIVES The presence of the arginine catabolic mobile element (ACME) in Staphylococcus aureus has been reported to enhance the colonization of the human host. The aim of this study was to determine the genetic organization of composite islands harbouring ACME. METHODS Two ACME-positive S. aureus isolates obtained during two different surveys conducted in the Netherlands and Poland were cha...
متن کاملFirst description of novel arginine catabolic mobile elements (ACMEs) types IV and V harboring a kdp operon in Staphylococcus epidermidis characterized by whole genome sequencing.
The arginine catabolic mobile element (ACME) was first described in the methicillin-resistant Staphylococcus aureus strain USA300 and is thought to facilitate survival on skin. To date three distinct ACME types have been characterized comprehensively in S. aureus and/or Staphylococcus epidermidis. Type I harbors the arc and opp3 operons encoding an arginine deaminase pathway and an oligopeptide...
متن کاملMolecular Investigation of Staphylococcal Cassette Chromosome mec (SCCmec) Elements Isolated from Intensive Care Unit
Background and Aims: Based on the results, Staphylococcus aureus is one of the serious infectious agents found in community and hospitals with remarkable potential for high morbidity and mortality around the globe. The present study was carried out for molecular investigation of methicillin-resistant Staphylococcus aureus strains and Staphylococcal Chromosomal Cassette mec (SCCmec) phenotypes i...
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